11月27日学术报告会

发文时间:2014-11-26
 
报告题目:甾体激素受体相关蛋白(TPR)家族在生长发育中的生物学作用(Functional analyses of steroid receptor associated-TPR protein family using animal models
人:雍伟东  教授、博士(中国医学科学院医学实验动物研究所)
    间:20141127(星期三)上午1000
    点:生物科技楼242
    办:茶与食品科技学院
 
 
雍伟东个人简历
教育经历
1996 - 2000    中国科学院,博士
1994 - 1996    内蒙古大学,硕士
1986 - 1990    兰州大学,学士
 
工作经验
2011-现在:中国医学科学院, 北京协和医学院医学实验动物研究所,协和学者特聘教授
2008-现在:美国,印第安那大学医学院,助理教授(研究系列)
2004-2008:美国,印第安那大学医学院,博士后
2000-2004:美国,普渡大学,博士后
 
发表文章
1.       Akiyama T, Shiraishi T, Qin J, Konno H, Akiyama N, Shinzawa M, Miyauchi M, Takizawa N, Yanai H, Ohashi H, Miyamoto-Sato E, Yanagawa H, Yong W, Shou W, Inoue J Mitochondria-nucleus shuttling FK506-binding protein 51 interacts with TRAF proteins and facilitates the RIG-I-like receptor-mediated expression of type I IFN. PLoS One. 2014 May 1;9(5):e95992
2.       Yong W, Spence JP, Eskay R, Fitz SD, Damadzic R, Lai D, Foroud T, Carr LG, Shekhar A, Chester JA, Heilig M, Liang T. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats.Alcohol ClinExp Res. 2014 May;38(5):1275-83. 
3.       Liu Y, Chen H, Ji G, Li B, Mohler PJ, Zhu Z, Yong W, Chen Z, Xu X, Xin H, Shou  W. Transgenic analysis of the role of FKBP12.6 in cardiac function andintracellular calcium release. Assay Drug Dev Technol. 2011 Dec;9(6):620-7.
4.       Hinds TD Jr, Stechschulte LA, Cash HA, Whisler D, Banerjee A, Yong W, Khuder SS, Kaw MK, Shou W, Najjar SM, Sanchez ER. Protein phosphatase 5 mediates lipidmetabolism through reciprocal control of glucocorticoid receptor and peroxisomeproliferator-activated receptor-γ (PPARγ). J Biol Chem. 2011 Dec16;286(50):42911-22.
5.       Zhang W, Chen H, Wang Y, Yong W, Zhu W, Liu Y, Wagner GR, Payne RM, Field LJ, Xin H, Cai CL, Shou W. Tbx20 transcription factor is a downstream mediator forbone morphogenetic protein-10 in regulating cardiac ventricular wall development and function. J Biol Chem. 2011 Oct 21;286(42):36820-9.
6.       Maruyama M, Li BY, Chen H, Xu X, Song LS, Guatimosim S, Zhu W, Yong W, ZhangW, Bu G, Lin SF, Fishbein MC, Lederer WJ, Schild JH, Field LJ, Rubart M, Chen PS,Shou W. FKBP12 is a critical regulator of the heart rhythm and the cardiacvoltage-gated sodium current in mice. Circ Res. 2011 Apr 29;108(9):1042-52.
7.       Chen H, Yong W (co-1st author), Terry D. Hinds, Jr., Zuocheng Yang, Yuhong Zhou, Martin J. Cohn, Edwin R. Sanchez, Weinian Shou Fkbp52 Regulates Androgen Receptor Transactivation Activity and Male Urethra Morphogenesis, JBC. 2010 July 6. [Epub ahead of print]
8.       Warrier M, Hinds TD Jr, Ledford KJ, Cash HA, Patel PR, Bowman TA, Stechschulte LA, Yong W, Shou W, Najjar SM, Sanchez ER. Susceptibility to Diet-Induced Hepatic Steatosis and Glucocorticoid Resistance in FK506-Binding Protein 52-Deficient Mice. Endocrinology. 2010 Apr 28. [Epub ahead of print]
9.       Wolf IM, Periyasamy S, Hinds T Jr, Yong W, Shou W, Sanchez ER. Targeted ablation reveals a novel role of FKBP52 in gene-specific regulation of glucocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol. 2009 Jan;113(1-2):36-45.
10.   Banerjee A, Periyasamy S, Wolf IM, Hinds TD Jr, Yong W, Shou W, Sanchez ER. Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins. Biochemistry. 2008 Sep 30;47(39):10471-80.
11.   Held MA, Penning B, Brandt AS, Kessans SA, Yong W, Scofield SR, Carpita NC. Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley. Proc NatlAcadSci U S A. 2008 Dec 23;105(51):20534-9
12.   Weidong Yong, ShidingBao, Hanying Chen, Edwin R. Sánchez, Weinian Shou. Mice lacking protein phosphatase 5 are defective in ATM-mediated cell cycle arrest. J BiolChem 2007 May 18;282(20):14690-4
13.   Weidong Yong, Zuocheng Yang, SumudraPeriyasamy, Hanying Chen, SelculYucel, Wei Li, Leanne Y. Lin, Irene M. Wolf, Martin J. Cohn, Laurence S. Baskin, Edwin R. Sánchez, Weinian Shou. Essential Role for Co-Chaperone FKBP52 but not FKBP51 in Androgen Receptor-Mediated Signaling and Physiology. J Biol Chem. 2007 Feb 16; 282(7): 5026-36
14.   Yang Z, Wolf IM, Chen H, Periyasamy S, Chen Z, Yong W, Shi S, Zhao W, Xu J, Srivastava A, Sanchez ER, Shou W. FKBP52 is Essential to Uterine Reproductive Physiology Controlled By the Progesterone Receptor A Isoform. Mol Endocrinol. 2006 Sep 30;353(2):283-93
15.   Chen H, Yong W (co-1st author), Ren S, Shen W, He Y, Cox KA, Zhu W, Li W, Soonpaa M, Payne RM, Franco D, Field LJ, Rosen V, Wang Y, Shou W. Overexpression of bone morphogenetic protein 10 in myocardium disrupts cardiac postnatal hypertrophic growth. J Biol Chem. 2006 Sep 15;281(37):27481-91
16.   Yong Weidong, Link B, O'Malley R, Tewari J, Hunter CT, Lu CA, Li X, Bleecker AB, Koch KE, McCann MC, McCarty DR, Patterson SE, Reiter WD, Staiger C, Thomas SR, Vermerris W, Carpita NC. Genomics of plant cell wall biogenesis. Planta. 2005 Aug;221(6):747-51
17.   Weidong Yong, Yun-yuanXu, Wen-zhongXu, Xin Wang, Ning Li, Jin-song Wu, Tie-bing Liang, Kang Chong, Zhi-hongXu, Ke-hui Tan and Zhi-qing Zhu. Vernalization-induced flowering in wheat is mediated by a lectin-like gene VER2. Planta 2003, 217: 261–270 
18.   JiaShiqian, Weidong  Yong, Chong Kang, Tan Kehui, et al Existence of homologous sequences corresponding to cDNA of the ver gene in diverse higher plant species , Cell Research. 2001, Dec; 11 (4): 265-271
19.   Liang Tiebing, Yong Weidong, Tan Kehui et al. Vernalization has effect on spike initiation, differentiation and grain setting in winter wheat. Acta Botanic, 2001;43 (9): 788-794
20.   Kang Guobing, Xu Yong, Yong Weidong et al. Cloning of the low temperature induced cDNA in cucumber by difference display PCR. Acta Botanic, 2001; 43(9):955-959
21.   Yong Weidong, Chong Kang, XuZhihong, Tan Kehui, et al. Gene control of flowering time in higher plants. Chinese Science Bulletin. 2000, 45(18):1633-42
22.   Yong Weidong, Chong Kang, Liang Tiebing, Tan Kehui, XuZhihong. Cloning and characterization of vernalization relative gene cDNA 3’end. Chinese Science Bulletin. 1999; 44(14), 623-627
23.   Zhao Dazhong, Yong Weidong, Chong Kang. Review of Advance in Flower Studies in Higher Plant . Chinese Bulletin of Botany, 1999, 16(5):157-162
24.   Yong Weidong, Liang Tiebing, Li Cong, Song Yanru. PhbB, phbC genes expression in E. coli and obtaining of transgenic potato plants. Acta Botanic,1998 40(7): 615-621
25.   Yong Weidong, XieAnyong, Song Yanru. Biodegrade Plastic---Hopes of resolving white pollution (review). Plant Journal, 1996(1): 23-28
 
主持及参加科研项目
1.     2012-2015国家高技术发展计划(863)“人类疾病大鼠模型资源集成与关键技术研发”。项目主持
2.       2013 – 2016 国家自然基金“蛋白磷酸酶5p53 功能的调节及其在p53 相关肿瘤发生中作用机理的研究”。项目主持
3.       2013-2017 国家科技支撑计划(973)计划“原始生殖细胞发生和性腺发育的机制研究”课题负责人
4.       12/01/09 – 11/30/10住持,美国国家健康研究院(NIH)   Pilot Project 55 The major goal of this project  is to using Zinc Finger Nuclease (ZFN) Technology to Generate NPY Knockout Rat.
5.     09/01/05 – 08/31/10参加,美国国家健康研究院(NIH) R01 DK70127 TPR proteins in steroid receptor signaling and physiology     
6.     07/01/07 – 06/31/12参加,美国国家健康研究院(NIH) R01 HL81092Molecular Pathways in Myocardium Development
7.     12/01/05- 11/31/09参加,美国国家健康研究院(NIH)R01 DK73402-01Role of FKBP52 in androgen signaling and hypospadias